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The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence

Received: 31 December 2013     Published: 20 February 2014
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Abstract

Quorum sensing (QS) plays a vital role in controlling virulence in bacterial species. Vibrio cholerae, the main causative agent of cholera uses chemical signals to control virulence and biofilm formation. QS Always depend on the secretion and detection of signaling molecules known as auto inducers. Contrary to other bacteria that cause virulence at High cell density (HCD) when they attain a specific threshold, reverse is the case for V. Cholerae. At Low cell density (LCD), activation in the expression of virulence gene by V. cholerae destabilizes HapR while stabilizing AphA. The activation of AphA structural genes result in the expression of CT and TCP virulence together with the formation of biofilm. At HCD, the coherence of the two quorum-sensing auto-inducers (CAI-1 and AI-2) represses the expression of the virulence genes by activating HapR which in turn synthesizes Hap protease that acts as a detachase to get rid of the virulence genes and biofilm formation. In this review, we outline the QS mechanism used by Vibrio cholerae to cause infection by the production of virulence factors. In addition, we examine how this infection can be minimize through the use of chemicals which act as either inhibitors or agonist to the QS system.

Published in Advances in Bioscience and Bioengineering (Volume 2, Issue 1)
DOI 10.11648/j.abb.20140201.11
Page(s) 1-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Virulence, Autoinducers, CAI-1, AI-2, LuxO, HapR, Aph A, QS Inhibitors

References
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Cite This Article
  • APA Style

    Bashir Mohammed Abubakar, Jibrin Ndejiko Mohammed, Abdulrahman Idris, Hamzat Ibiyeye Tijani, Saidu Haruna, et al. (2014). The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence. Advances in Bioscience and Bioengineering, 2(1), 1-7. https://doi.org/10.11648/j.abb.20140201.11

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    ACS Style

    Bashir Mohammed Abubakar; Jibrin Ndejiko Mohammed; Abdulrahman Idris; Hamzat Ibiyeye Tijani; Saidu Haruna, et al. The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence. Adv. BioSci. Bioeng. 2014, 2(1), 1-7. doi: 10.11648/j.abb.20140201.11

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    AMA Style

    Bashir Mohammed Abubakar, Jibrin Ndejiko Mohammed, Abdulrahman Idris, Hamzat Ibiyeye Tijani, Saidu Haruna, et al. The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence. Adv BioSci Bioeng. 2014;2(1):1-7. doi: 10.11648/j.abb.20140201.11

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  • @article{10.11648/j.abb.20140201.11,
      author = {Bashir Mohammed Abubakar and Jibrin Ndejiko Mohammed and Abdulrahman Idris and Hamzat Ibiyeye Tijani and Saidu Haruna and Yusuf Hindatu and Mohammed Sulaiman},
      title = {The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence},
      journal = {Advances in Bioscience and Bioengineering},
      volume = {2},
      number = {1},
      pages = {1-7},
      doi = {10.11648/j.abb.20140201.11},
      url = {https://doi.org/10.11648/j.abb.20140201.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20140201.11},
      abstract = {Quorum sensing (QS) plays a vital role in controlling virulence in bacterial species. Vibrio cholerae, the main causative agent of cholera uses chemical signals to control virulence and biofilm formation. QS Always depend on the secretion and detection of signaling molecules known as auto inducers. Contrary to other bacteria that cause virulence at High cell density (HCD) when they attain a specific threshold, reverse is the case for V. Cholerae. At Low cell density (LCD), activation in the expression of virulence gene by V. cholerae destabilizes HapR while stabilizing AphA. The activation of AphA structural genes result in the expression of CT and TCP virulence together with the formation of biofilm.  At HCD, the coherence of the two quorum-sensing auto-inducers (CAI-1 and AI-2) represses the expression of the virulence genes by activating HapR which in turn synthesizes Hap protease that acts as a detachase to get rid of the virulence genes and biofilm formation. In this review, we outline the QS mechanism used by Vibrio cholerae to cause infection by the production of virulence factors. In addition, we examine how this infection can be minimize through the use of chemicals which act as either inhibitors or agonist to the QS system.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence
    AU  - Bashir Mohammed Abubakar
    AU  - Jibrin Ndejiko Mohammed
    AU  - Abdulrahman Idris
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    T2  - Advances in Bioscience and Bioengineering
    JF  - Advances in Bioscience and Bioengineering
    JO  - Advances in Bioscience and Bioengineering
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    PB  - Science Publishing Group
    SN  - 2330-4162
    UR  - https://doi.org/10.11648/j.abb.20140201.11
    AB  - Quorum sensing (QS) plays a vital role in controlling virulence in bacterial species. Vibrio cholerae, the main causative agent of cholera uses chemical signals to control virulence and biofilm formation. QS Always depend on the secretion and detection of signaling molecules known as auto inducers. Contrary to other bacteria that cause virulence at High cell density (HCD) when they attain a specific threshold, reverse is the case for V. Cholerae. At Low cell density (LCD), activation in the expression of virulence gene by V. cholerae destabilizes HapR while stabilizing AphA. The activation of AphA structural genes result in the expression of CT and TCP virulence together with the formation of biofilm.  At HCD, the coherence of the two quorum-sensing auto-inducers (CAI-1 and AI-2) represses the expression of the virulence genes by activating HapR which in turn synthesizes Hap protease that acts as a detachase to get rid of the virulence genes and biofilm formation. In this review, we outline the QS mechanism used by Vibrio cholerae to cause infection by the production of virulence factors. In addition, we examine how this infection can be minimize through the use of chemicals which act as either inhibitors or agonist to the QS system.
    VL  - 2
    IS  - 1
    ER  - 

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Author Information
  • Department of Biological Sciences, Bauchi State University Gadau, P.M.B 065, Bauchi, Nigeria

  • Department of Microbiology, Ibrahim Badamasi Babangida University Lapai, P.M.B 011, Niger, Nigeria

  • Department of Microbiology, Kaduna State University, P.M.B. 2339, Kaduna, Nigeria

  • Faculty of Bioscience & Medical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor-bahru, Malaysia

  • Department of Biological Sciences, Gombe State University, PMB 0127, Gombe, Nigeria

  • Department of Biochemistry, Bauchi State University Gadau, P.M.B 065, Bauchi, Nigeria

  • Department of Biological Sciences, Gombe State University, PMB 0127, Gombe, Nigeria

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